Top quality 99% Exemestane
English name: Exemestane
6-methylenandrosta-1,4-diene-3,17-dione; 6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE; 10,13-dimethyl-6-methylidene-7,8,9 , 10,11,12,13,14,15,16-decahydrocyclopenta [a] phenanthrene-; EXEMESTANE; FCE-24304; AROMASIN; Exemestan; Exemestance
Molecular formula: C20H24O2
Molecular weight: 296.4
Melting point 155.13 ° C
Storage conditions Store at -20 ° C
Chemical properties White solid, melting point 190 ~ 192 ℃.
Use of second-generation aromatase inhibitors for the treatment of metastatic breast cancer and adjuvant therapy for early breast cancer.
Use of pharmaceutical raw materials, an irreversible steroid aromatase inactivator, can inhibit estrogen synthesis, reduce blood estrogen levels, for tamoxifen treatment after the progression of advanced postmenopausal breast cancer patients
Exemestane is an irreversible steroidal aromatase inactivator, the structure of the enzyme natural substrate androst-4-ene-3,17-dione in two similar to the pseudo substrate aromatase, by irreversibly bind to the active site of the enzyme and its inactivation (also known as "the role of self destructive suppression"). From the decreased estrogen levels in postmenopausal women in blood circulation, but the biosynthesis of corticosteroids and aldosterone in the adrenal gland had no obvious effect. In 600 times higher than the concentration of aromatase inhibition, the other steroidogenic enzyme in the pathway is not influenced.